Pre-UCLA – Lawson Lab

Ligand-induced and small-molecule control of substrate loading in a hexameric helicase

Lawson MR, Dyer K, Berger JM. Ligand-induced and small-molecule control of substrate loading in a hexameric helicase. Proceedings of the National Academy of Sciences. 2016 Nov 29;113(48):13714-13719.

Dynamics of release factor recycling during translation termination in bacteria. Nucleic Acids Research

Prabhakar A, Pavlov M, Zhang J, Indrisiunaite G, Wang J, Lawson MR, Ehrenberg M, Puglisi JD. Dynamics of release factor recycling during translation termination in bacteria. Nucleic Acids Research. 2023 Apr 27;gkad286.

A Fluorescent Assay to Monitor Ligand-Dependent Closure of the Hexameric Rho Helicase Ring

Lawson MR, Berger JM. A Fluorescent Assay to Monitor Ligand-Dependent Closure of the Hexameric Rho Helicase Ring. Methods Mol Biol. 2021 2209:133-142.

Mechanisms that ensure speed and fidelity in eukaryotic translation termination

Lawson MR*, Lessen LN*, Wang J, Prabhakar A, Corsepius NC, Green R, Puglisi JD. Mechanisms that ensure speed and fidelity in eukaryotic translation termination. Science. 2021 Aug 20;373(6557):876-882. * Denotes equal contribution

Tuning the sequence specificity of a transcription terminator

Lawson MR, Berger JM. Tuning the sequence specificity of a transcription terminator. Current Genetics. 2019 Jun;65(3):729-733.

Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein

Lawson MR, Ma W, Bellecourt MJ, Artsimovitch I, Martin A, Landick R, Schulten K, Berger JM. Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein. Molecular Cell. 2018 Sep 20;71(6):911-922.

Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proceedings of the National Academy of Sciences.

Thomsen ND, Lawson MR, Witkowsky LB, Qu S, Berger JM. Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proceedings of the National Academy of Sciences. 2016 Nov 29;113(48):E7691-E7700.

Characterization of a non-ribosomal peptide synthetase-associated diiron arylamine N-oxygenase from Pseudomonas syringae pv. phaseolicola.

Platter E, Lawson M, Marsh C, Sazinsky MH. (2011). Characterization of a non-ribosomal peptide synthetase-associated diiron arylamine N-oxygenase from Pseudomonas syringae pv. phaseolicola. Archives of Biochemistry and Biophysics, 508(1):39-45.

Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.

Vogel M, Lawson M, Sippl W, Conrad U, Roos W. (2010). Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification. Journal of Biological Chemistry, 285(24):18397-406.

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

Lawson M, Uciechowska U, Rumpf T, Jung M, Sippl W. (2010). Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins). Biochimica et Biophysica Acta. 1799(10-12):726-39.